Density Regulated Protein antibody (AA 80-130)

Catalog No. ABIN6991992

The Rabbit Polyclonal anti-Density Regulated Protein antibody (ABIN6991992) specifically detects Density Regulated Protein in WB, ELISA, IF and IHC (p). The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for Density Regulated Protein antibody (AA 80-130) (ABIN6991992)

Target: Density Regulated Protein (DENR) (Density-Regulated Protein (DENR))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Density Regulated Protein antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-Density Regulated Protein Antibody

Binding Specificity: AA 80-130

Specificity: DENR antibody is human, mouse and rat reactive.

Purification: DENR antibody is affinity chromatography purified via peptide column.

Immunogen: DENR antibody was raised against an 18 amino acid peptide near the center of human DENR. The immunogen is located within amino acids 80 - 130 of DENR.

Isotype: IgG

Application Details

Application Notes: DENR antibody can be used for detection of DENR by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for Immunohistochemistry at 5 μ,g/mL. For Immunoflorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: DENR Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: DENR antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for Density Regulated Protein

Target: Density Regulated Protein (DENR) (Density-Regulated Protein (DENR))

Alternative Name: DEN

Background: DENR (density-regulated protein), also designated DRP or smooth muscle cell associated protein 3 (SMAP-3), is a 198 amino acid protein that may be involved in the translation of target mRNAs by scanning and recognition of the initiation codon (1). It plays a role in the modulation of the translational profile of a subset of cancer-related mRNAs when recruited to the translational initiation complex by the oncogene MCTS1 (2,3). DENR contains a SUI1 domain and is found in a variety of tissues with highest levels present in skeletal and cardiac muscle. It is up-regulated in ovarian and breast cancer cells by ERBB2 overexpression (4).

Molecular Weight: Predicted: 22 kDa

Observed: 22 kDa

Gene ID: 8562

NCBI Accession: NP_003668

UniProt: O43583