Density Regulated Protein antibody (AA 80-130)

Catalog No. ABIN6991992

Product Details anti-Density Regulated Protein Antibody

Target: Density Regulated Protein (DENR) (Density-Regulated Protein (DENR))

Binding Specificity: AA 80-130

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Density Regulated Protein antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: DENR antibody is human, mouse and rat reactive.

Purification: DENR antibody is affinity chromatography purified via peptide column.

Immunogen: DENR antibody was raised against an 18 amino acid peptide near the center of human DENR. The immunogen is located within amino acids 80 - 130 of DENR.

Isotype: IgG

Application Details

Application Notes: DENR antibody can be used for detection of DENR by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for Immunohistochemistry at 5 μ,g/mL. For Immunoflorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: DENR Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: DENR antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for Density Regulated Protein

Target: Density Regulated Protein (DENR) (Density-Regulated Protein (DENR))

Alternative Name: DEN (DENR Products)

Synonyms: DRP antibody, DRP1 antibody, SMAP-3 antibody, DENR antibody, 1500003K04Rik antibody, drp antibody, drp1 antibody, smap-3 antibody, MGC79758 antibody, MGC107862 antibody, im:6891640 antibody, zgc:113309 antibody, zgc:92629 antibody, denr antibody, Denr antibody, DDBDRAFT_0205981 antibody, DDBDRAFT_0266779 antibody, DDB_0205981 antibody, DDB_0266779 antibody, density regulated re-initiation and release factor antibody, density-regulated protein L homeolog antibody, density-regulated protein antibody, Density-regulated protein antibody, density regulated reinitiation and release factor antibody, DENR antibody, denr.L antibody, Denr antibody, denr antibody, EHI_065830 antibody, CpipJ_CPIJ009942 antibody, MCYG_07531 antibody, Tsp_00169 antibody

Background: DENR (density-regulated protein), also designated DRP or smooth muscle cell associated protein 3 (SMAP-3), is a 198 amino acid protein that may be involved in the translation of target mRNAs by scanning and recognition of the initiation codon (1). It plays a role in the modulation of the translational profile of a subset of cancer-related mRNAs when recruited to the translational initiation complex by the oncogene MCTS1 (2,3). DENR contains a SUI1 domain and is found in a variety of tissues with highest levels present in skeletal and cardiac muscle. It is up-regulated in ovarian and breast cancer cells by ERBB2 overexpression (4).

Molecular Weight: Predicted: 22 kDa

Observed: 22 kDa

Gene ID: 8562

NCBI Accession: NP_003668

UniProt: O43583