IFIT1 antibody (C-Term)

Catalog No. ABIN6991993

Product Details anti-IFIT1 Antibody

Target: IFIT1 (Interferon-Induced Protein with Tetratricopeptide Repeats 1 (IFIT1))

Binding Specificity: AA 290-340, C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IFIT1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: IFIT1 antibody is human, mouse and rat reactive. At least three isoforms of IFIT1 are known to exist. This antibody is predicted to not cross-react with other members of the IFIT protein family.

Purification: IFIT1 antibody is affinity chromatography purified via peptide column.

Immunogen: IFIT1 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human IFIT1. The immunogen is located within amino acids 290 - 340 of IFIT1.

Isotype: IgG

Application Details

Application Notes: IFIT1 antibody can be used for detection of IFIT1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for Immunohistochemistry at 5 μ,g/mL. For Immunoflorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in rat samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: IFIT1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: IFIT1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for IFIT1

Target: IFIT1 (Interferon-Induced Protein with Tetratricopeptide Repeats 1 (IFIT1))

Alternative Name: IFIT1 (IFIT1 Products)

Synonyms: C56 antibody, G10P1 antibody, IFI-56 antibody, IFI-56K antibody, IFI56 antibody, IFIT-1 antibody, IFNAI1 antibody, ISG56 antibody, P56 antibody, RNM561 antibody, Ifi56 antibody, Garg16 antibody, DKFZp469C2331 antibody, interferon induced protein with tetratricopeptide repeats 1 antibody, interferon-induced protein with tetratricopeptide repeats 1 antibody, IFIT1 antibody, Ifit1 antibody, LOC488947 antibody, ifit1 antibody, LOC100058990 antibody, LOC100139670 antibody, LOC100475782 antibody

Background: The interferon-induced protein with tetratricopeptide repeats 1 (IFIT1) protein is a member of a family of tetratricopeptide repeat-containing proteins whose transcription is upregulated by interferons, virus infection, and molecular patterns such as dsRNA or lipopolysaccharides (1,2). These proteins have been suggested to induce anti-viral cellular activities in response to infection (2). Together with the interferon-induced transmembrane protein 1 (IFITM1), IFIT1 inhibits the replication of the Hepatitis C virus, suggesting that it may be useful in the development of therapeutic treatments (3).

Molecular Weight: Predicted: 53 kDa

Observed: 53 kDa

Gene ID: 3434

NCBI Accession: NP_001539

UniProt: P09914

Pathways: Hepatitis C