OASL antibody (N-Term)

Catalog No. ABIN6991998

The Rabbit Polyclonal anti-OASL antibody (ABIN6991998) specifically detects OASL in WB, ELISA, ICC and IF. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for OASL antibody (N-Term) (ABIN6991998)

Target: OASL (2'-5' Oligoadenylate Synthetase-Like (OASL))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This OASL antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Product Details anti-OASL Antibody

Binding Specificity: N-Term

Specificity: OASL antibody is human, mouse and rat reactive.

Purification: OASL antibody is affinity chromatography purified via peptide column.

Immunogen: OASL antibody was raised against a 17 amino acid peptide near the amino terminus of human OASL. The immunogen is located within the first 50 amino acids of OASL.

Isotype: IgG

Application Details

Application Notes: OASL antibody can be used for detection of OASL by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for Immunocytochemistry at 2.5 μ,g/mL. For Immunoflorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in mouse samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: OASL Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: OASL antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for OASL

Target: OASL (2'-5' Oligoadenylate Synthetase-Like (OASL))

Alternative Name: OASL

Background: OASL (2'-5'-oligoadenylate synthetase-like), also known as p59OASL or TRIP14 (thyroid receptor-interacting protein 14), is a 514 amino acid protein that exists as two alternatively spliced isoforms, designated p56 and p30, and contains two ubiquitin-like domains (1). It is widely expressed in a variety of tissues and interacts with the ligand binding domain of the thyroid receptor (TR) and is able to bind double-stranded RNA and DNA, possibly playing a role in RNA degradation and the overall inhibition of protein synthesis (2-3). Methyl CpG-binding protein 1 (MBD1), which functions as a transcriptional repressor, was identified as a strong p59 OASL interactor (4).

Molecular Weight: Predicted: 57 kDa

Observed: 65 kDa

Gene ID: 8638

NCBI Accession: NP_003724

UniProt: Q15646