MFN1 antibody (N-Term)

Catalog No. ABIN6992021

The Rabbit Polyclonal anti-MFN1 antibody is suitable to detect MFN1 in samples from Human, Mouse and Rat. It has been validated for WB, ELISA and ICC.

Quick Overview for MFN1 antibody (N-Term) (ABIN6992021)

Target: MFN1 (Mitofusin 1 (MFN1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MFN1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Product Details anti-MFN1 Antibody

Binding Specificity: AA 20-70, N-Term

Specificity: MFN1 antibody is human, mouse and rat reactive. MFN1 antibody is predicted to not cross-react with MFN2.

Purification: MFN1 antibody is affinity chromatography purified via peptide column.

Immunogen: MFN1 antibody was raised against a 17 amino acid peptide near the amino terminus of human MFN1. The immunogen is located within amino acids 20 - 70 of MFN1.

Isotype: IgG

Application Details

Application Notes: MFN1 antibody can be used for detection of MFN1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for Immunocytochemistry at 5 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunocytochemistry in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: MFN1 antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: MFN1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for MFN1

Target: MFN1 (Mitofusin 1 (MFN1))

Alternative Name: MFN1

Background: Mitofusin 1 (MFN1) and the related protein MFN2 are mitochondrial membrane GTPase proteins that play a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes (1,2). MFN1 and MFN2 form homotypic and heterotypic complexes and coordinately regulate mitochondrial fusion and are essential for embryonic development (3). When ectopically expressed, MFN1 inhibits the apoptosis-associated amino-terminal conformation change in the apoptotic protein Bax but not its mitochondrial translocation, indicating that MFN1 is involved in the regulating the activation of Bax on the outer mitochondrial membrane (4).

Molecular Weight: Predicted: 82 kDa

Observed: 83 kDa

Gene ID: 55669

NCBI Accession: NP_284941

UniProt: Q8IWA4