PIK3C3 antibody (N-Term)

Catalog No. ABIN6992032

This Rabbit Polyclonal antibody specifically detects PIK3C3 in WB and ELISA. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for PIK3C3 antibody (N-Term) (ABIN6992032)

Target: PIK3C3 (Phosphoinositide-3-Kinase, Class 3 (PIK3C3))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PIK3C3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-PIK3C3 Antibody

Binding Specificity: AA 130-180, N-Term

Specificity: PIK3C3 antibody is human, mouse and rat reactive.

Purification: PIK3C3 antibody is affinity chromatography purified via peptide column.

Immunogen: PIK3C3 antibody was raised against an 18 amino acid peptide near the amino terminus of human PIK3C3. The immunogen is located within amino acids 130 - 180 of PIK3C3.

Isotype: IgG

Application Details

Application Notes: PIK3C3 antibody can be used for detection of PIK3C3 by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PIK3C3 antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: PIK3C3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for PIK3C3

Target: PIK3C3 (Phosphoinositide-3-Kinase, Class 3 (PIK3C3))

Alternative Name: PIK3C3

Background: PI 3-kinase p100 (phosphoinositide-3-kinase p100 subunit), also known as hVps34 or PIK3C3 (phosphoinositide-3-kinase class III), is a member of the PI3/PI4-kinase family (1). It is a catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate and ubiquitously expressed with a highest expression in skeletal muscle (1,2). PIK3C3 is involved in the endosome to lysosome transport and plays important roles in intracellular membrane trafficking and autophagy (3-5).

Molecular Weight: Predicted: 91, 98 kDa

Observed: 98 kDa

Gene ID: 5289

NCBI Accession: NP_002638

UniProt: Q8NEB9

Pathways: AMPK Signaling, Activation of Innate immune Response, Inositol Metabolic Process, Toll-Like Receptors Cascades, Autophagy