CADM3 antibody (AA 220-270)

Catalog No. ABIN6992066

Product Details anti-CADM3 Antibody

Target: CADM3 (Cell Adhesion Molecule 3 (CADM3))

Binding Specificity: AA 220-270

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CADM3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: CADM3 antibody is human, mouse and rat reactive. At least three isoforms are known to exist, this antibody will only detect the two longest isoforms. CADM3 antibody is predicted to not cross-react with other members of the CADM protein family.

Purification: CADM3 antibody is affinity chromatography purified via peptide column.

Immunogen: CADM3 antibody was raised against a 16 amino acid peptide near the center of human CADM3. The immunogen is located within amino acids 220 - 270 of CADM3.

Isotype: IgG

Application Details

Application Notes: CADM3 antibody can be used for detection of CADM3 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: CADM3 antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: CADM3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for CADM3

Target: CADM3 (Cell Adhesion Molecule 3 (CADM3))

Alternative Name: CADM3 (CADM3 Products)

Synonyms: BIgR antibody, IGSF4B antibody, NECL1 antibody, Necl-1 antibody, TSLL1 antibody, synCAM3 antibody, Igsf4b antibody, Necl1 antibody, SynCAM3 antibody, Tsll1 antibody, necl1 antibody, cell adhesion molecule 3 antibody, cell adhesion molecule 3 S homeolog antibody, CADM3 antibody, Cadm3 antibody, cadm3.S antibody

Background: Cell adhesion molecule 3 (CADM3) is a member of a family of immunoglobulin-like, calcium-independent cell-cell adhesion molecules (1,2). CADM3 localizes to non-junctional contact sites of presynaptic nerve terminals, axons and glia cell processes and is thought to play an important role in the formation of synapses, axon bundles and myelinated axons (3). Recently, CADM3 has been shown to suppress the growth and tumorigenic ability of colon cancer cells, indicating that it can act as a tumor suppressor (4).

Molecular Weight: Predicted: 44, 48 kDa

Observed: 50 kDa

Gene ID: 57863

NCBI Accession: NP_067012

UniProt: Q8N126

Pathways: Cell-Cell Junction Organization