NOSTRIN antibody (C-Term)

Catalog No. ABIN6992085

Product Details anti-NOSTRIN Antibody

Target: NOSTRIN (Nitric Oxide Synthase Trafficker (NOSTRIN))

Binding Specificity: AA 430-480, C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NOSTRIN antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: NOSTRIN antibody is human, mouse and rat reactive. At least four isoforms are known to exist, this antibody will detect all four isoforms.

Purification: NOSTRIN antibody is affinity chromatography purified via peptide column.

Immunogen: NOSTRIN antibody was raised against a 17 amino acid peptide near the carboxy terminus of human NOSTRIN. The immunogen is located within amino acids 430 - 480 of NOSTRIN.

Isotype: IgG

Application Details

Application Notes: NOSTRIN antibody can be used for detection of NOSTRIN by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: NOSTRIN antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: NOSTRIN antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for NOSTRIN

Target: NOSTRIN (Nitric Oxide Synthase Trafficker (NOSTRIN))

Alternative Name: NOSTRIN (NOSTRIN Products)

Synonyms: NOSTRIN antibody, MGC171848 antibody, Daip2 antibody, mDaIP2 antibody, DaIP2 antibody, nitric oxide synthase trafficking antibody, nitric oxide synthase trafficking L homeolog antibody, nitric oxide synthase trafficker antibody, NOSTRIN antibody, nostrin antibody, nostrin.L antibody, Nostrin antibody

Background: NOSTRIN. also known as endothelial nitric oxide synthase traffic inducer, is a member of the Pombe Cdc15 homology (PCH) family of proteins which may function as the modulator of the subcellular localisation and activity of endothelial nitric oxide synthase (eNOS) (1,2). It decreases NOS3 activity by inducing its translocation away from the plasma membrane (3). NOSTRIN typically exists as a trimer and is expressed in the vascular endothelial cells of highly vascularized tissues such as placenta, lung, kidney and heart. NOSTRIN is necessary for proper vascular development in zebrafish and postnatal retinal angiogenesis in mice (4,5).

Molecular Weight: Predicted: 47, 53, 56, 62 kDa

Observed: 68 kDa

Gene ID: 115677

NCBI Accession: NP_443178

UniProt: Q8IVI9