ADRM1 antibody (AA 210-260)

Catalog No. ABIN6992113

Product Details anti-ADRM1 Antibody

Target: ADRM1 (Adrm1) (Adhesion Regulating Molecule 1 (Adrm1))

Binding Specificity: AA 210-260

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ADRM1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: ADRM1 antibody is human, mouse and rat reactive. At least two isoforms of ADRM1 are know to exist, this antibody will detect both isoforms.

Purification: ADRM1 antibody is affinity chromatography purified via peptide column.

Immunogen: ADRM1 antibody was raised against a 19 amino acid peptide near the center of human ADRM1. The immunogen is located within amino acids 210 - 260 of ADRM1.

Isotype: IgG

Application Details

Application Notes: ADRM1 antibody can be used for detection of ADRM1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL.

Antibody validated: Western Blot in mouse samples and Immunohistochemistry in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: ADRM1 antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: ADRM1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for ADRM1

Target: ADRM1 (Adrm1) (Adhesion Regulating Molecule 1 (Adrm1))

Alternative Name: ADRM1 (Adrm1 Products)

Synonyms: arm-1 antibody, gp110 antibody, rpn13 antibody, xoom antibody, ADRM1 antibody, adrm1 antibody, ARM-1 antibody, ARM1 antibody, GP110 antibody, 1110063P18Rik antibody, 2510006J17Rik antibody, AA408205 antibody, AU043535 antibody, Arm1 antibody, Gp110 antibody, Rpn13 antibody, adrm1a antibody, adrm1b antibody, fa12d09 antibody, wu:fa10g10 antibody, wu:fa12d09 antibody, zgc:56107 antibody, zgc:77256 antibody, adhesion regulating molecule 1 antibody, ADRM1 antibody, 19S proteasome regulatory subunit antibody, ADRM1 protein antibody, adrm1 antibody, ADRM1 antibody, CpipJ_CPIJ002929 antibody, SJAG_04211 antibody, Adrm1 antibody

Background: The adhesion-regulating molecule 1 (ADRM1) is thought to be involved in protein recruitment and cell adhesion and functions as a proteasomal ubiquitin receptor (1). ADRM1 promotes the activity of UCH-L5 and plays a role in lymphocyte homing. The carboxy-terminal domain of mammalian ADRM1 serves to bind and enhance the isopeptidase activity of UCHL5/UCH37, perhaps serving as a mechanism to accelerate ubiquitin chain disassembly (2,3). ADRM1 expression is induced by IFN-gamma in some cancer cell lines and its expression is upregulated in other metastatic cells, suggesting a role in carcinogenesis (4,5).

Molecular Weight: Predicted: 45 kDa

Observed: 48 kDa

Gene ID: 11047

NCBI Accession: NP_783163

UniProt: Q16186

Pathways: Positive Regulation of Endopeptidase Activity