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DIRAS3 antibody (C-Term)

DIRAS3 Reactivity: Human WB, ELISA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6992120
  • Target See all DIRAS3 Antibodies
    DIRAS3 (DIRAS Family, GTP-Binding RAS-Like 3 (DIRAS3))
    Binding Specificity
    • 2
    • 2
    • 1
    • 1
    C-Term
    Reactivity
    • 22
    • 1
    • 1
    Human
    Host
    • 19
    • 3
    Rabbit
    Clonality
    • 20
    • 2
    Polyclonal
    Conjugate
    • 10
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This DIRAS3 antibody is un-conjugated
    Application
    • 13
    • 12
    • 8
    • 7
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA
    Specificity
    DIRAS3 antibody is human specific.
    Purification
    DIRAS3 antibody is affinity chromatography purified via peptide column.
    Immunogen
    DIRAS3 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human DIRAS3. The immunogen is located within the last 50 amino acids of DIRAS3.
    Isotype
    IgG
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    Discover our top product DIRAS3 Primary Antibody
  • Application Notes
    DIRAS3 antibody can be used for detection of DIRAS3 by Western blot at 1 - 2 μ,g/mL.

    Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    DIRAS3 antibody is supplied in PBS containing 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,4 °C
    Storage Comment
    DIRAS3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
  • Target
    DIRAS3 (DIRAS Family, GTP-Binding RAS-Like 3 (DIRAS3))
    Alternative Name
    DIRAS3 (DIRAS3 Products)
    Synonyms
    DIRAS3 antibody, arhi antibody, noey2 antibody, ARHI antibody, NOEY2 antibody, DIRAS family GTPase 3 antibody, DIRAS family GTP binding RAS like 3 antibody, DIRAS3 antibody, diras3 antibody
    Background
    DIRAS3 is a member of the ras superfamily, and is expressed in normal ovarian and breast epithelial cells, but not in ovarian and breast cancers. It is an imprinted gene, with mono-allelic expression of the paternal allele, which is associated with growth suppression and down-regulation of cyclin D1 promoter activity and induction of p21 (WAF/CIP1). Thus, this gene appears to be a putative tumor suppressor gene whose function is abrogated in ovarian and breast cancers (1). DIRAS3 has been shown to induce autophagy in human ovarian cancer cells by blocking PI3K signaling, inhibiting the mammalian target of rapamycin (TOR), upregulating ATG4, and colocalizing with LC3 in autophagosomes (2). DIRAS also interacts with C-RAF and downregulates mitogen-activated protein kinase kinases (MEK) to restrict cell migration (3).
    Molecular Weight
    Predicted: 25 kDa

    Observed: 24 kDa
    Gene ID
    9077
    NCBI Accession
    NP_004666
    UniProt
    O95661
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