LRRC8A antibody (N-Term)

Catalog No. ABIN6992155

This Rabbit Polyclonal antibody specifically detects LRRC8A in WB, ELISA and IHC (p). It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for LRRC8A antibody (N-Term) (ABIN6992155)

Target: LRRC8A (Leucine Rich Repeat Containing 8 Family, Member A (LRRC8A))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LRRC8A antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-LRRC8A Antibody

Binding Specificity: AA 60-110, N-Term

Specificity: LRRC8A antibody is human, mouse and rat reactive.

Purification: LRRC8A antibody is affinity chromatography purified via peptide column.

Immunogen: LRRC8A antibody was raised against a 15 amino acid peptide near the amino terminus of human LRRC8A. The immunogen is located within amino acids 60 - 110 of LRRC8A.

Isotype: IgG

Application Details

Application Notes: LRRC8A antibody can be used for detection of LRRC8A by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL.

Antibody validated: Western Blot in mouse samples and Immunohistochemistry in rat samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: LRRC8A antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: LRRC8A antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for LRRC8A

Target: LRRC8A (Leucine Rich Repeat Containing 8 Family, Member A (LRRC8A))

Alternative Name: LRRC8A

Background: The leucine rich repeat containing 8 family member A protein (LRRC8A) belongs the LRRC8 family of proteins within the LRR superfamily of proteins, which are involved in diverse biological processes, including cell adhesion, cellular trafficking, and hormone-receptor interactions (1,2). LRRC8A is a four-pass transmembrane protein that plays a role in B cell development. Defects in this gene cause autosomal dominant non-Bruton type agammaglobulinemia, an immunodeficiency disease resulting from defects in B cell maturation (1). LRRC8A has also been shown to be an essential component of the volume-regulated anion channel VRAC (3).

Molecular Weight: Predicted: 89 kDa

Observed: 95 kDa

Gene ID: 56262

NCBI Accession: NP_062540

UniProt: Q8IWT6