Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

DIS3L2 antibody (C-Term)

DIS3L2 Reactivity: Human, Mouse, Rat WB, ELISA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6992168
  • Target See all DIS3L2 Antibodies
    DIS3L2 (DIS3-Like Exonuclease 2 (DIS3L2))
    Binding Specificity
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 720-770, C-Term
    Reactivity
    • 36
    • 19
    • 19
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 27
    • 9
    • 1
    Rabbit
    Clonality
    • 29
    • 8
    Polyclonal
    Conjugate
    • 12
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This DIS3L2 antibody is un-conjugated
    Application
    • 25
    • 13
    • 7
    • 6
    • 5
    • 1
    Western Blotting (WB), ELISA
    Specificity
    DIS3L2 antibody is human, mouse and rat reactive. At least three isoforms of DIS3L2 are known to exist, this antibody will only detect the longest isoform. DIS3L2 is predicted to not cross-react with DIS3 or DIS3L.
    Purification
    DIS3L2 antibody is affinity chromatography purified via peptide column.
    Immunogen
    DIS3L2 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human DIS3L2. The immunogen is located within amino acids 720 - 770 of DIS3L2.
    Isotype
    IgG
    Top Product
    Discover our top product DIS3L2 Primary Antibody
  • Application Notes
    DIS3L2 antibody can be used for detection of DIS3L2 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL.

    Antibody validated: Western Blot in mouse samples and Immunohistochemistry in rat samples. All other applications and species not yet tested.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    DIS3L2 antibody is supplied in PBS containing 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,4 °C
    Storage Comment
    DIS3L2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
  • Target
    DIS3L2 (DIS3-Like Exonuclease 2 (DIS3L2))
    Alternative Name
    DIS3L2 (DIS3L2 Products)
    Synonyms
    RGD1560168 antibody, DIS3L2 antibody, DKFZp469O0522 antibody, FAM6A antibody, PRLMNS antibody, hDIS3L2 antibody, 4930429A22Rik antibody, 8030493P09Rik antibody, DIS3-like 3'-5' exoribonuclease 2 antibody, DIS3 like 3'-5' exoribonuclease 2 antibody, DIS3-like exonuclease 2 antibody, Dis3l2 antibody, DIS3L2 antibody, LOC100344728 antibody
    Background
    The exosome is involved in a multitude of cellular RNA processing and degradation events (1). DIS3, also known as exosome complex exonuclease RRP44, is a ribonuclease that acts directly in the processing, turnover, and surveillance of a large number of distinct RNA species (2). DIS3L2 is a paralog of DIS3, but unlike DIS3 is located in the cytoplasm (3). DIS3L2 defines a novel eukaryotic RNA degradation pathway and preferentially targets uridylated RNA (4). DIS3L2 mutations have also been associated with sporadic Wilms tumors (3).
    Molecular Weight
    Predicted: 97 kDa

    Observed: 94 kDa
    Gene ID
    129563
    NCBI Accession
    NP_689596
    UniProt
    Q8IYB7
    Pathways
    Stem Cell Maintenance
You are here:
Support