SRPK1 antibody (N-Term)

Catalog No. ABIN6992178

The Rabbit Polyclonal anti-SRPK1 antibody (ABIN6992178) specifically detects SRPK1 in WB, ELISA and IHC (p). The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for SRPK1 antibody (N-Term) (ABIN6992178)

Target: SRPK1 (SRSF Protein Kinase 1 (SRPK1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SRPK1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-SRPK1 Antibody

Binding Specificity: N-Term

Specificity: SRPK1 antibody is human, mouse and rat reactive. Multiple isoforms of SRPK1 are known to exist, this antibody will detect all except isoforms b and e. SRPK1 antibody is predicted to not cross-react with SRPK2.

Purification: SRPK1 Antibody is affinity chromatography purified via peptide column.

Immunogen: SRPK1 antibody was raised against a 19 amino acid peptide from near the amino terminus of human SRPK1. The immunogen is located within the first 50 amino acids of SRPK1.

Isotype: IgG

Application Details

Application Notes: SRPK1 antibody can be used for the detection of SRPK1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry at 5 μ,g/mL.

Antibody validated: Western Blot in mouse samples and Immunohistochemistry in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: SRPK1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: SRPK1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for SRPK1

Target: SRPK1 (SRSF Protein Kinase 1 (SRPK1))

Alternative Name: SRPK1

Background: SRPK1 and SRPK2, two Arginine/serine-rich (SR) protein-specific kinases constitute control circuits to regulate both constitutive and alternative pre-mRNA splicing and coordinate splicing with transcription in cells (1). They are highly specific for the phosphorylation of these RS proteins, and highly expressed in testis (1,2). SRPK1 plays a role in the condensation of sperm chromatin and controls the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis (3,4).

Molecular Weight: Predicted: 54, 72, 91 kDa

Observed: 91 kDa

Gene ID: 6732

NCBI Accession: NP_003128

UniProt: Q96SB4

Pathways: Toll-Like Receptors Cascades