BRCA2 antibody

Catalog No. ABIN7234156

This anti-BRCA2 antibody is a Rabbit Polyclonal antibody detecting BRCA2 in WB, IHC and IF. Suitable for Human and Rat.

Quick Overview for BRCA2 antibody (ABIN7234156)

Target: BRCA2 (Breast Cancer 2, Early Onset (BRCA2))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BRCA2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-BRCA2 Antibody

Characteristics: Polyclonal Antibody

Purification: Antigen Affinity Purification

Immunogen: Recombinant Human Breast cancer type 2 susceptibility protein

Isotype: IgG

Application Details

Application Notes: WB 1:1000-1:3000 IHC 1:100-1:200 IF 1:100-1:400

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.05 % Proclin300 and 50 % glycerol, pH 7.4.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for BRCA2

Target: BRCA2 (Breast Cancer 2, Early Onset (BRCA2))

Alternative Name: BRCA2

Background: Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele.

Molecular Weight:

Observed_MW: 384 kDa

Calculated_MW: 384 kDa

UniProt: P51587

Pathways: DNA Damage Repair, M Phase, Maintenance of Protein Location