DRG1 antibody

Catalog No. ABIN7236838

Product Details anti-DRG1 Antibody

Target: DRG1 (Developmentally Regulated GTP Binding Protein 1 (DRG1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DRG1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Characteristics: Polyclonal Antibody

Purification: Affinity purification

Immunogen: Recombinant protein of human DRG1

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:50-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for DRG1

Target: DRG1 (Developmentally Regulated GTP Binding Protein 1 (DRG1))

Alternative Name: DRG1 (DRG1 Products)

Synonyms: NEDD3 antibody, wu:fb06g12 antibody, zgc:64124 antibody, xdrg antibody, xdrg1 antibody, MGC122865 antibody, AA408859 antibody, AI132520 antibody, Nedd3 antibody, developmentally regulated GTP binding protein 1 antibody, developmentally regulated GTP binding protein 1 L homeolog antibody, DRG1 antibody, Drg1 antibody, drg1 antibody, drg1.L antibody

Background: DRG1 (developmentally regulated GTP binding protein 1), also known as NEDD3 (neural precursor cell expressed developmentally down-regulated protein 3), is a 367 amino acid protein that localizes to the cytoplasm and belongs to the GTP1/OBG family. Expressed at high levels in heart, kidney and skeletal muscle and at lower levels in brain, liver, placenta, lung, colon and spleen, DRG1 binds to TAL1 and TAL2 and is thought to play a role in cell proliferation and differentiation, as well as in apoptosis, suggesting a role in tumor formation and metastasis. DRG1 is subject to polyubiquitination and sumoylation, the former of which induces proteolytic degradation. The gene encoding DRG1 maps to human chromosome 22, which houses over 500 genes and is the second smallest human chromosome. Mutations in several of the genes that map to chromosome 22 are involved in the development of Phelan-McDermid syndrome, Neurofibromatosis type 2, autism and schizophrenia.

Molecular Weight: 41 kDa

UniProt: Q9Y295