NUAK1 antibody

Catalog No. ABIN7238549

This anti-NUAK1 antibody is a Rabbit Polyclonal antibody detecting NUAK1 in ELISA and IHC. Suitable for Human and Mouse.

Quick Overview for NUAK1 antibody (ABIN7238549)

Target: NUAK1 (NUAK Family, SNF1-Like Kinase, 1 (NUAK1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NUAK1 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Product Details anti-NUAK1 Antibody

Characteristics: Polyclonal Antibody

Purification: Affinity purification

Immunogen: Synthetic peptide of human NUAK1

Isotype: IgG

Application Details

Application Notes: IHC 1:25-1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.6 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for NUAK1

Target: NUAK1 (NUAK Family, SNF1-Like Kinase, 1 (NUAK1))

Alternative Name: NUAK1

Background: NUAK family SNF1-like kinase 1also known asAMPK-related protein kinase 5(ARK5) is anenzymethat in humans is encoded by theNUAK1gene. Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1.

NCBI Accession: NP_055655

UniProt: O60285