ERN2 antibody

Catalog No. ABIN7238930

The Rabbit Polyclonal anti-ERN2 antibody is suitable to detect ERN2 in samples from Human. It has been validated for ELISA and IHC.

Quick Overview for ERN2 antibody (ABIN7238930)

Target: ERN2 (Endoplasmic Reticulum To Nucleus Signaling 2 (ERN2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ERN2 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Product Details anti-ERN2 Antibody

Characteristics: Polyclonal Antibody

Purification: Affinity purification

Immunogen: Synthetic peptide of human ERN2

Isotype: IgG

Application Details

Application Notes: IHC 1:50-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for ERN2

Target: ERN2 (Endoplasmic Reticulum To Nucleus Signaling 2 (ERN2))

Alternative Name: ERN2

Background: The accumulation of unfolded proteins within the endoplasmic recticulum (ER) of yeast and mammalian cells activates the unfolded protein response (UPR) pathway and leads to the transcription of ER-specific genes involved in protein folding. The activation of the UPR requires the ER transmembrane kinase IRE1p (for inositol-requiring and ER-to-nucleus signaling protein). IRE1α and IRE1β are two mammalian homologs of the yeast IRE1p. These related proteins localize to the ER lumen and contain both a short transmembrane domain that spans the ER membrane and a cytosolic Ser/Thr kinase domain. IRE1 activation involves the oligomerization and trans-phosphorylation of the cytosolic portion of the proteins, which then potentiates its intrinsic kinase activity and, in turn, stimulates transcription of UPR-targeted genes.

NCBI Accession: NP_150296

UniProt: Q76MJ5