ITPR2 antibody

Catalog No. ABIN7239110

This anti-ITPR2 antibody is a Rabbit Polyclonal antibody detecting ITPR2 in IHC and ELISA. Suitable for Human.

Quick Overview for ITPR2 antibody (ABIN7239110)

Target: ITPR2 (Inositol 1,4,5-Trisphosphate Receptor, Type 2 (ITPR2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ITPR2 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Product Details anti-ITPR2 Antibody

Characteristics: Polyclonal Antibody

Purification: Affinity purification

Immunogen: Synthetic peptide of human ITPR2

Isotype: IgG

Application Details

Application Notes: IHC 1:50-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.9 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for ITPR2

Target: ITPR2 (Inositol 1,4,5-Trisphosphate Receptor, Type 2 (ITPR2))

Alternative Name: ITPR2

Background: Inositol 1,4,5-triphosphate (IP3) functions as a second messenger for a myriad of extracellular stimuli including hormones, growth factors and neurotransmitters. Receptor tyrosine kinases indirectly increase the intracellular levels of IP3 through the activation of phospholipases such as phospholipase C (PLC), which convert phosphatidylinositol-4,5 bisphosphate into IP3 and diacylglycerol (DAG). The inositol 1,4,5-triphosphate receptor, IP3R, acts as an inositol triphosphate (IP3)-gated calcium release channel in a variety of cell types. Three IP3 receptor subtypes have been described and are designated IP3R-I, IP3R-II and IP3R-III. IP3R-I is the predominant IP3R subtype expressed in neuronal tissues and the central nervous system, but is also expressed at high levels in the liver.

NCBI Accession: NP_002214

UniProt: Q14571

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Thyroid Hormone Synthesis, Myometrial Relaxation and Contraction, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma