SPAG1 antibody

Catalog No. ABIN7242443

The Rabbit Polyclonal anti-SPAG1 antibody is suitable to detect SPAG1 in samples from Human. It has been validated for WB and ELISA.

Quick Overview for SPAG1 antibody (ABIN7242443)

Target: SPAG1 (Sperm Associated Antigen 1 (SPAG1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SPAG1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-SPAG1 Antibody

Characteristics: Polyclonal Antibody

Purification: Affinity purification

Immunogen: Synthetic peptide of human SPAG1

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.3 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for SPAG1

Target: SPAG1 (Sperm Associated Antigen 1 (SPAG1))

Alternative Name: SPAG1

Background: The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm agglutinating antibodies from an infertile woman. Furthermore, immunization of female rats with the recombinant human protein reduced fertility. This protein localizes to the plasma membrane of germ cells in the testis and to the post-acrosomal plasma membrane of mature spermatozoa. Recombinant polypeptide binds GTP and exhibits GTPase activity. Thus, this protein may regulate GTP signal transduction pathways involved in spermatogenesis and fertilization. Two transcript variants of this gene encode the same protein.

Molecular Weight: 104 kDa

NCBI Accession: NP_003105

UniProt: Q07617