PNOC antibody

Catalog No. ABIN7243640

Product Details anti-PNOC Antibody

Target: PNOC (Prepronociceptin (PNOC))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PNOC antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Characteristics: Polyclonal Antibody

Purification: Affinity purification

Immunogen: Synthetic peptide of human PNOC

Isotype: IgG

Application Details

Application Notes: IHC 1:50-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.4 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for PNOC

Target: PNOC (Prepronociceptin (PNOC))

Alternative Name: PNOC (PNOC Products)

Synonyms: N23K antibody, Npnc1 antibody, PPNOC antibody, N/OFQ antibody, OFQ/N antibody, PNOC antibody, OFQ antibody, prepronociceptin antibody, PNOC antibody, Pnoc antibody

Background: Nociception, a pain response mechanism, occurs in response to stimuli that threaten the integrity of an organism. The first synapses produced as a result of the initiation of nociception are modulated by excitatory amino acids (glutamate and aspartate) and many peptides (substance P, CGRP, CCK, endogenous opioids). Nociceptin (also designated orphanin FQ) is a neuronal peptide that is similar to opioid peptides. Nociceptin activates KOR-3 (kappa-type opioid receptor, also designated ORL1), a G protein-coupled receptor. Although similar to dynorphin A, a kappa opioid peptide, nociceptin functions to make animals hyperreactive to nociceptive stimulations. Nociceptin is also involved in locomotor behavior and may be involved in the modulation of synaptic plasticity in learning and memory.

NCBI Accession: NP_006219

UniProt: Q13519