SMAD4 antibody

Catalog No. ABIN7243955

The Rabbit Polyclonal anti-SMAD4 antibody (ABIN7243955) specifically detects SMAD4 in ELISA and IHC. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for SMAD4 antibody (ABIN7243955)

Target: SMAD4 (SMAD Family Member 4 (SMAD4))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SMAD4 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Product Details anti-SMAD4 Antibody

Characteristics: Polyclonal Antibody

Purification: Affinity purification

Immunogen: Fusion protein of human SMAD4

Isotype: IgG

Application Details

Application Notes: IHC 1:50-200, ELISA 1:1000-2000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for SMAD4

Target: SMAD4 (SMAD Family Member 4 (SMAD4))

Alternative Name: SMAD4

Background: This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to TGF-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome.

Molecular Weight: 60 kDa

UniProt: Q13485

Pathways: Cell Division Cycle, Chromatin Binding, Autophagy