IRGC antibody

Catalog No. ABIN7245341

The Rabbit Polyclonal anti-IRGC antibody is suitable to detect IRGC in samples from Human and Rat. It has been validated for ELISA and IHC.

Quick Overview for IRGC antibody (ABIN7245341)

Target: IRGC (Immunity-Related GTPase Family, Cinema (IRGC))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IRGC antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Product Details anti-IRGC Antibody

Characteristics: Polyclonal Antibody

Purification: Antigen affinity purification

Immunogen: Synthetic peptide of human IRGC

Isotype: IgG

Application Details

Application Notes: IHC 1:30-1:150, ELISA 1:5000-1:10000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.78 mg/mL

Buffer: PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for IRGC

Target: IRGC (Immunity-Related GTPase Family, Cinema (IRGC))

Alternative Name: IRGC

Background: Immunity-related GTPases (IRG) (also known as p47 GTPases) are a family of GTPase proteins found in vertebrates, which play critical roles in mediating innate resistance to intracellular pathogens. IRG genes have been found in a number of mammals and lower species including mice, rats, zebrafish and humans. Most of the mouse genes contain interferon-stimulated response elements which mediate transcriptional activation by IFNs. In humans, only two IRG genes have been found: human IRGC encodes a full-length IRG protein that, like the mouse homologue, is constitutively expressed in testis, while human IRGM encodes a considerably truncated protein that is constitutively expressed in cultured cells including some macrophage cell lines. As the two human genes IRGC and IRGM are not subject to IFN control, it has been suggested that the host resistance mechanism supported by IRG proteins in the mouse is lacking in humans.

UniProt: Q6NXR0