TUBGCP4 antibody

Catalog No. ABIN7004071

The Rabbit Polyclonal anti-TUBGCP4 antibody (ABIN7004071) specifically detects TUBGCP4 in ELISA and WB. The antibody is reactive with Human and Mouse samples.

Quick Overview for TUBGCP4 antibody (ABIN7004071)

Target: TUBGCP4 (Tubulin, gamma Complex Associated Protein 4 (TUBGCP4))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TUBGCP4 antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Product Details anti-TUBGCP4 Antibody

Characteristics: Polyclonal Antibody

Purification: Antigen affinity purification

Immunogen: Fusion protein of human TUBGCP4

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, ELISA 1:5000-1:10000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.6 mg/mL

Buffer: PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for TUBGCP4

Target: TUBGCP4 (Tubulin, gamma Complex Associated Protein 4 (TUBGCP4))

Alternative Name: TUBGCP4

Background: This gene encodes a component of the gamma-tubulin ring complex, which is required for microtubule nucleation. In mammalian cells, the protein localizes to centrosomes in association with gamma-tubulin. Crystal structure analysis revealed a structure composed of five helical bundles arranged around conserved hydrophobic cores. An exposed surface area located in the C-terminal domain is essential and sufficient for direct binding to gamma-tubulin. Mutations in this gene that alter microtubule organization are associated with microcephaly and chorioretinopathy. Alternative splicing results in multiple transcript variants.TUBGCP4 (Tubulin Gamma Complex Associated Protein 4) is a Protein Coding gene. Diseases associated with TUBGCP4 include Microcephaly And Chorioretinopathy, Autosomal Recessive, 3 and Autosomal Recessive Chorioretinopathy-Microcephaly Syndrome. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and Cell Cycle, Mitotic. GO annotations related to this gene include structural constituent of cytoskeleton. An important paralog of this gene is TUBGCP6.

Molecular Weight:

Observed_MW: Refer to figures

Calculated_MW: 76 kDa

UniProt: Q9UGJ1

Pathways: M Phase