TUBGCP4 antibody (AA 160-240)

Catalog No. ABIN7215030

This Rabbit Polyclonal antibody specifically detects TUBGCP4 in ELISA, WB, IHC and IF. It exhibits reactivity toward Human and Mouse.

Quick Overview for TUBGCP4 antibody (AA 160-240) (ABIN7215030)

Target: TUBGCP4 (Tubulin, gamma Complex Associated Protein 4 (TUBGCP4))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TUBGCP4 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-TUBGCP4 Antibody

Binding Specificity: AA 160-240

Purpose: Rabbit Anti-GCP4 Polyclonal Antibody

Specificity: GCP4 Polyclonal Antibody detects endogenous levels of GCP4 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the Internal region of human GCP4 at AA range: 160-240

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,IHC 1:100-1:300,ELISA 1:10000,IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for TUBGCP4

Target: TUBGCP4 (Tubulin, gamma Complex Associated Protein 4 (TUBGCP4))

Alternative Name: GCP4

Background: TUBGCP4, 76P, GCP4, Gamma-tubulin complex component 4, GCP-4, hGCP4, Gamma-ring complex protein 76 kDa, h76p, hGrip76TUBGCP4 encodes a component of the gamma-tubulin ring complex, gamma-tubulin complex component 4, which is required for microtubule nucleation. In mammalian cells, the protein localizes to centrosomes in association with gamma-tubulin. Crystal structure analysis revealed a structure composed of five helical bundles arranged around conserved hydrophobic cores. An exposed surface area located in the C-terminal domain is essential and sufficient for direct binding to gamma-tubulin. Mutations in this gene that alter microtubule organization are associated with microcephaly and chorioretinopathy. Alternative splicing results in multiple transcript variants.

Molecular Weight: 76kD

Gene ID: 27229

UniProt: Q9UGJ1

Pathways: M Phase