IFT57 antibody

Catalog No. ABIN7247168

This anti-IFT57 antibody is a Rabbit Polyclonal antibody detecting IFT57 in IHC and ELISA. Suitable for Human and Mouse.

Quick Overview for IFT57 antibody (ABIN7247168)

Target: IFT57 (Intraflagellar Transport 57 Homolog (IFT57))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IFT57 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Product Details anti-IFT57 Antibody

Characteristics: Polyclonal Antibody

Purification: Antigen affinity purification

Immunogen: Fusion protein of human IFT57

Isotype: IgG

Application Details

Application Notes: IHC 1:50-1:300, ELISA 1:5000-1:10000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.5 mg/mL

Buffer: PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for IFT57

Target: IFT57 (Intraflagellar Transport 57 Homolog (IFT57))

Alternative Name: IFT57

Background: Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator, however the relevance of such function remains unclear.

UniProt: Q9NWB7

Pathways: Hedgehog Signaling, Positive Regulation of Endopeptidase Activity