HUWE1 antibody

Catalog No. ABIN7248203

Product Details anti-HUWE1 Antibody

Target: HUWE1 (HECT, UBA and WWE Domain Containing 1, E3 Ubiquitin Protein Ligase (HUWE1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HUWE1 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Characteristics: Polyclonal Antibody

Purification: Antigen affinity purification

Immunogen: Synthetic peptide of human HUWE1

Isotype: IgG

Application Details

Application Notes: IHC 1:10-1:50, ELISA 1:5000-1:10000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.8 mg/mL

Buffer: PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for HUWE1

Target: HUWE1 (HECT, UBA and WWE Domain Containing 1, E3 Ubiquitin Protein Ligase (HUWE1))

Alternative Name: HUWE1 (HUWE1 Products)

Synonyms: ARF-BP1 antibody, HECTH9 antibody, HSPC272 antibody, Ib772 antibody, LASU1 antibody, MULE antibody, URE-B1 antibody, UREB1 antibody, 5430439H10Rik antibody, AU041296 antibody, Arf-bp1 antibody, C430014N20Rik antibody, C80292 antibody, Gm1718 antibody, Mule antibody, Ureb1 antibody, HUWE1 antibody, si:dkey-242a8.2 antibody, Huwe1 antibody, mule antibody, ib772 antibody, lasu1 antibody, ureb1 antibody, hecth9 antibody, arf-bp1 antibody, hspc272 antibody, HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase antibody, HECT, UBA and WWE domain containing 1 antibody, E3 ubiquitin-protein ligase HUWE1 antibody, HUWE1 antibody, Huwe1 antibody, huwe1 antibody, LOC100123214 antibody, LOC100380641 antibody

Background: This gene encodes a protein containing a C-terminal HECT (E6AP type E3 ubiquitin protein ligase) domain that functions as an E3 ubiquitin ligase. The encoded protein is required for the ubiquitination and subsequent degradation of the anti-apoptotic protein Mcl1 (myeloid cell leukemia sequence 1 (BCL2-related)). This protein also ubiquitinates the p53 tumor suppressor, core histones, and DNA polymerase beta. Mutations in this gene are associated with Turner type X-linked syndromic mental retardation.

UniProt: Q7Z6Z7