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MOB2 antibody

MOB2 Reactivity: Human, Mouse ELISA, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7248908
  • Target See all MOB2 Antibodies
    MOB2 (MOB Kinase Activator 2 (MOB2))
    Reactivity
    • 28
    • 17
    • 1
    Human, Mouse
    Host
    • 24
    • 3
    • 1
    Rabbit
    Clonality
    • 26
    • 2
    Polyclonal
    Conjugate
    • 11
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This MOB2 antibody is un-conjugated
    Application
    • 21
    • 14
    • 14
    • 14
    • 3
    • 1
    • 1
    • 1
    • 1
    ELISA, Immunohistochemistry (IHC)
    Characteristics
    Polyclonal Antibody
    Purification
    Antigen affinity purification
    Immunogen
    Synthetic peptide of human MOB2
    Isotype
    IgG
    Top Product
    Discover our top product MOB2 Primary Antibody
  • Application Notes
    IHC 1:40-1:200, ELISA 1:5000-1:10000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1.08 mg/mL
    Buffer
    PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    MOB2 (MOB Kinase Activator 2 (MOB2))
    Alternative Name
    MOB2 (MOB2 Products)
    Synonyms
    HCCA2 antibody, 1110017M21Rik antibody, 2700078K21Rik antibody, AI256456 antibody, Mmh antibody, Hcca2 antibody, RGD1562983 antibody, hcca2 antibody, mob2 antibody, mob2.1 antibody, p5a5 antibody, Mob2 antibody, MOB kinase activator 2 antibody, MOB kinase activator 2 L homeolog antibody, multigenic obesity QTL 2 antibody, MOB2 antibody, Mob2 antibody, mob2.1.L antibody, Mobq2 antibody
    Background
    MOB2 (Mps one binder kinase activator-like 2), also known as HCCA2 (Hepatocellular carcinoma-associated gene 2), is a 467 amino acid protein that belongs to the MOB1/phocein family. MOB2 is expressed in lung, spleen, brain, and fetal liver. It is highly expressed in hepatocellular carcinoma. MOB2 is localized in the perinuclear region of the cytoplasm in liver cancer tissues and colocalizes with MAD2L2 in the nucleus of Hela cells. MOB2 is characterized by two N-glycosylation sites, six N-myristolylation sites, two Src homology 3 (SH3), and several phosphorylation motifs which indicate that this protein may play a role in an intracellular signal transduction cascade. MOB2 binds to and regulates the autophosphorylation of the related human serine/threonine kinase 38 (NDR1) and serine/threonine kinase 38L(NDR2). It has been shown that MOB2 plays a critical role in cell cycle regulation. Overexpression of the protein during the G0/G1 phase inhibits cell proliferation causing cell cycle arrest. Stimulates the autophosphorylation and kinase activity of STK38 and STK38L.
    UniProt
    Q70IA6
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