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TERT antibody

TERT Reactivity: Human WB, ELISA, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7248992
  • Target See all TERT Antibodies
    TERT (Telomerase Reverse Transcriptase (TERT))
    Reactivity
    • 102
    • 37
    • 20
    • 5
    • 1
    • 1
    Human
    Host
    • 105
    • 5
    • 1
    Rabbit
    Clonality
    • 97
    • 14
    Polyclonal
    Conjugate
    • 50
    • 8
    • 7
    • 6
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This TERT antibody is un-conjugated
    Application
    • 65
    • 48
    • 38
    • 27
    • 17
    • 14
    • 13
    • 12
    • 7
    • 7
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    Characteristics
    Polyclonal Antibody
    Purification
    Affinity purification
    Immunogen
    Synthetic peptide of human TERT
    Isotype
    IgG
    Top Product
    Discover our top product TERT Primary Antibody
  • Application Notes
    WB 1:200-1:1000, IHC 1:25-1:100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1.1 mg/mL
    Buffer
    PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    TERT (Telomerase Reverse Transcriptase (TERT))
    Alternative Name
    TERT (TERT Products)
    Background
    Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified, the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity.
    Molecular Weight
    127 kDa
    NCBI Accession
    NP_937983
    UniProt
    O14746
    Pathways
    Telomere Maintenance
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