ALKBH8 antibody
Quick Overview for ALKBH8 antibody (ABIN7249214)
Target
See all ALKBH8 AntibodiesReactivity
Host
Clonality
Conjugate
Application
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Characteristics
- Polyclonal Antibody
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Purification
- Antigen affinity purification
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Immunogen
- Full length fusion protein
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Isotype
- IgG
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anti-AlkB, Alkylation Repair Homolog 8 (ALKBH8) (AA 1-230) antibody
ALKBH8 Reactivity: Human WB, IHC Host: Rabbit Polyclonal unconjugated
anti-AlkB, Alkylation Repair Homolog 8 (ALKBH8) (AA 494-523), (C-Term) antibodyALKBH8 Reactivity: Human WB, IHC (p), FACS Host: Rabbit Polyclonal RB19549 unconjugated
anti-AlkB, Alkylation Repair Homolog 8 (ALKBH8) (N-Term) antibodyALKBH8 Reactivity: Human, Guinea Pig, Horse, Cow, Monkey WB Host: Rabbit Polyclonal unconjugated
anti-AlkB, Alkylation Repair Homolog 8 (ALKBH8) (AA 1-230) antibodyALKBH8 Reactivity: Human ELISA, IHC Host: Rabbit Polyclonal unconjugated
anti-AlkB, Alkylation Repair Homolog 8 (ALKBH8) (AA 141-190) antibodyALKBH8 Reactivity: Human, Mouse, Guinea Pig, Horse, Dog, Monkey WB Host: Rabbit Polyclonal unconjugated
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Application Notes
- WB 1:500-1:2000, IHC 1:25-1:100, ELISA 1:5000-1:10000
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Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- 0.6 mg/mL
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Buffer
- PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4
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Preservative
- Sodium azide
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Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Storage
- -20 °C
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Storage Comment
- Store at -20°C. Avoid freeze / thaw cycles.
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- ALKBH8 (AlkB, Alkylation Repair Homolog 8 (ALKBH8))
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Alternative Name
- ALKBH8
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Background
- ALKBH8 (alkylated DNA repair protein AlkB homolog 8) is a 664 amino acid protein that is encoded by a gene located on chromosome 11. ALKBH8 contains one RRM (RNA recognition motif) domain and belongs to the AlkB family of proteins. ALKBH8 is one of many homologs of the Escherichia coli protein AlkB. AlkB functions to protect DNA and RNA against damage from environmental methylating compounds by directly reversing 1-methyladenine (1-meA) and 3-methylcytosine (3-meC) cytotoxic alkylation lesions in DNA and RNA. The enzyme acts by oxidative demethylation, utilizing ferrous iron and alpha-ketoglutarate as cofactors, 2-oxoglutarate as a co-substrate and molecular oxygen as the oxidizing agent. Three isoforms exist for ALKBH8 due alternative splicing of the gene.
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Molecular Weight
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Observed_MW: Refer to figures
Calculated_MW: 75 kDa
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UniProt
- Q96BT7
Target
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