beta Catenin antibody

Catalog No. ABIN7249752

This anti-beta Catenin antibody is a Mouse Monoclonal antibody detecting beta Catenin in WB and IHC. Suitable for Human, Mouse and Rat.

Quick Overview for beta Catenin antibody (ABIN7249752)

Target: beta Catenin (CATNB) (Catenin, beta (CATNB))

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This beta Catenin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: 4A3H3

Product Details anti-beta Catenin Antibody

Characteristics: Monoclonal Antibody

Purification: Affinity purification

Immunogen: Recombinant protein corresponding to Mouse beta-catenin

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:1000, IHC 1:100-1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 420 μg/mL

Buffer: PBS with 0.02 % sodium azide, 1 % BSA and 50 % glycerol, pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for beta Catenin

Target: beta Catenin (CATNB) (Catenin, beta (CATNB))

Alternative Name: Catenin beta

Background: CTNNB1,also known as β-Catenin,is an evolutionarily conserved,multifunctional intracellular protein. CTNNB1 was originally identified in cell adherens junctions (Ajs) where it functions to bridge the cytoplasmic domain of cadherins to a-catenin and the actin cytoskeleton. Besides its essential role in the Ajs,CTNNB1 is also a key downstream component of the canonical Wnt pathway that plays diverse and critical roles in embryonic development and adult tissue homeostasis. Deregulation of CTNNB1 activity is associated with multiple diseases including cancers. .

Molecular Weight:

Observed_MW: 92 kDa

Calculated_MW: 92 kDa

UniProt: P35222, Q02248, Q9WU82

Pathways: Peptide Hormone Metabolism