NR3C2 antibody
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- Target See all NR3C2 Antibodies
- NR3C2 (Nuclear Receptor Subfamily 3, Group C, Member 2 (NR3C2))
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Reactivity
- Human, Rat, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This NR3C2 antibody is un-conjugated
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Application
- Immunohistochemistry (IHC)
- Characteristics
- Polyclonal Antibody
- Purification
- Affinity purification
- Immunogen
- KLH conjugated Synthetic peptide corresponding to Mouse Mineralocorticoid receptor
- Isotype
- IgG
- Top Product
- Discover our top product NR3C2 Primary Antibody
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- Application Notes
- IHC 1:200-1:800
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1.3 mg/mL
- Buffer
- PBS with 0.02 % sodium azide, 1 % BSA and 50 % glycerol, pH 7.4
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- NR3C2 (Nuclear Receptor Subfamily 3, Group C, Member 2 (NR3C2))
- Alternative Name
- Mineralocorticoid receptor (NR3C2 Products)
- Background
- This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants.
- UniProt
- P08235, Q8VII8, P22199
- Pathways
- ACE Inhibitor Pathway, Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway
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