Survivin antibody

Catalog No. ABIN7249940

This Rabbit Polyclonal antibody specifically detects Survivin in WB and IHC. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for Survivin antibody (ABIN7249940)

Target: Survivin (BIRC5) (Baculoviral IAP Repeat-Containing 5 (BIRC5))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Survivin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-Survivin Antibody

Characteristics: Polyclonal Antibody

Purification: Affinity purification

Immunogen: Recombinant protein corresponding to Mouse Survivin

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:200-1:600

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 450 μg/mL

Buffer: PBS with 0.02 % sodium azide, 1 % BSA and 50 % glycerol, pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Survivin

Target: Survivin (BIRC5) (Baculoviral IAP Repeat-Containing 5 (BIRC5))

Alternative Name: Survivin

Background: This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Molecular Weight:

Observed_MW: 16-18 kDa

Calculated_MW: 16 kDa

UniProt: O15392, O70201, Q9JHY7

Pathways: Apoptosis, Cell Division Cycle, Nuclear Hormone Receptor Binding