Caspase 3 p12 (Cleaved-Asp175) antibody
Reactivity: Human
WB, ELISA, IF, IHC (p)
Host: Rabbit
Polyclonal
unconjugated
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- Target
- Caspase 3 p12
-
Binding Specificity
- Cleaved-Asp175
- Reactivity
- Human
-
Host
- Rabbit
-
Clonality
- Polyclonal
-
Conjugate
- Un-conjugated
- Application
- Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Characteristics
- Polyclonal Antibody
- Purification
- Affinity purification
- Immunogen
- Synthesized peptide derived from the Internal region of human Caspase-3 p12
- Isotype
- IgG
-
anti-Caspase 3 p12 (Asp175), (cleaved) antibody
Reactivity: Human WB, ELISA, IHC Host: Rabbit Polyclonal unconjugated
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- Application Notes
- WB 1:500-2000, IHC 1:50-300, IF 1:50-300
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PBS with 0.02 % sodium azide, 0.5 % BSA and 50 % glycerol, pH 7.4
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Avoid freeze / thaw cycles.
-
- Target
- Caspase 3 p12
- Alternative Name
- CASP3 p12
- Background
- Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin.
- Molecular Weight
-
Observed_MW: 20+35 kDa
Calculated_MW: 32 kDa
- UniProt
- P42574
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