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CDK5R1 antibody

CDK5R1 Reactivity: Human, Mouse, Rat IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7257908
  • Target See all CDK5R1 Antibodies
    CDK5R1 (Cyclin-Dependent Kinase 5, Regulatory Subunit 1 (p35) (CDK5R1))
    Reactivity
    • 54
    • 47
    • 20
    • 12
    • 11
    • 10
    • 10
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 51
    • 17
    • 1
    Rabbit
    Clonality
    • 45
    • 24
    Polyclonal
    Conjugate
    • 24
    • 6
    • 5
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CDK5R1 antibody is un-conjugated
    Application
    • 55
    • 38
    • 34
    • 16
    • 14
    • 13
    • 13
    • 10
    • 7
    • 5
    • 5
    • 3
    • 1
    • 1
    Immunofluorescence (IF)
    Characteristics
    Polyclonal Antibody
    Purification
    Affinity purification
    Immunogen
    Recombinant fusion protein of human CDK5R1 (NP_003876.1).
    Isotype
    IgG
    Top Product
    Discover our top product CDK5R1 Primary Antibody
  • Application Notes
    IF 1:50-1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    CDK5R1 (Cyclin-Dependent Kinase 5, Regulatory Subunit 1 (p35) (CDK5R1))
    Alternative Name
    CDK5R1 (CDK5R1 Products)
    Synonyms
    CDK5P35 antibody, CDK5R antibody, NCK5A antibody, p23 antibody, p25 antibody, p35 antibody, p35nck5a antibody, cdk5r1 antibody, zgc:92814 antibody, CDK5R1 antibody, Cdk5r antibody, P25/P35 antibody, D11Bwg0379e antibody, Xp35.1 antibody, cyclin dependent kinase 5 regulatory subunit 1 antibody, cyclin-dependent kinase 5, regulatory subunit 1b (p35) antibody, cyclin-dependent kinase 5 regulatory subunit 1 antibody, S100 calcium binding protein A9 antibody, cyclin-dependent kinase 5, regulatory subunit 1 (p35) antibody, cyclin-dependent kinase 5, regulatory subunit 1 (p35) L homeolog antibody, CDK5R1 antibody, cdk5r1b antibody, Cdk5r1 antibody, S100A9 antibody, cdk5r1.L antibody
    Target Type
    Viral Protein
    Background
    The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5), the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease.
    Gene ID
    8851
    UniProt
    Q15078
    Pathways
    Stem Cell Maintenance, Regulation of Cell Size, Positive Regulation of Endopeptidase Activity
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