Titin antibody

Catalog No. ABIN7259346

Product Details anti-Titin Antibody

Target: Titin (TTN)

Reactivity: Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Titin antibody is un-conjugated

Application: Immunofluorescence (IF)

Characteristics: Polyclonal Antibody

Purification: Affinity purification

Immunogen: Recombinant Protein of human TTN.

Isotype: IgG

Application Details

Application Notes: IF 1:50-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Titin

Target: Titin (TTN)

Alternative Name: TTN (TTN Products)

Synonyms: CMD1G antibody, CMH9 antibody, CMPD4 antibody, EOMFC antibody, HMERF antibody, LGMD2J antibody, MYLK5 antibody, TMD antibody, 1100001C23Rik antibody, 2310036G12Rik antibody, 2310057K23Rik antibody, 2310074I15Rik antibody, AF006999 antibody, AV006427 antibody, D330041I19Rik antibody, D830007G01Rik antibody, L56 antibody, mdm antibody, shru antibody, UNC-22 antibody, titin antibody, TTN antibody, Ttn antibody, titin antibody, TTNLOC100620261 antibody

Background: This gene encodes a large abundant protein of striated muscle. The product of this gene is divided into two regions, a N-terminal I-band and a C-terminal A-band. The I-band, which is the elastic part of the molecule, contains two regions of tandem immunoglobulin domains on either side of a PEVK region that is rich in proline, glutamate, valine and lysine. The A-band, which is thought to act as a protein-ruler, contains a mixture of immunoglobulin and fibronectin repeats, and possesses kinase activity. An N-terminal Z-disc region and a C-terminal M-line region bind to the Z-line and M-line of the sarcomere, respectively, so that a single titin molecule spans half the length of a sarcomere. Titin also contains binding sites for muscle associated proteins so it serves as an adhesion template for the assembly of contractile machinery in muscle cells. It has also been identified as a structural protein for chromosomes. Alternative splicing of this gene results in multiple transcript variants. Considerable variability exists in the I-band, the M-line and the Z-disc regions of titin. Variability in the I-band region contributes to the differences in elasticity of different titin isoforms and, therefore, to the differences in elasticity of different muscle types. Mutations in this gene are associated with familial hypertrophic cardiomyopathy 9, and autoantibodies to titin are produced in patients with the autoimmune disease scleroderma.

Gene ID: 7273

UniProt: Q8WZ42