KRR1 antibody

Catalog No. ABIN7261074

The Rabbit Polyclonal anti-KRR1 antibody is suitable to detect KRR1 in samples from Human, Mouse and Rat. It has been validated for WB and IF.

Quick Overview for KRR1 antibody (ABIN7261074)

Target: KRR1 (KRR1, Small Subunit (SSU) Processome Component, Homolog (KRR1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KRR1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-KRR1 Antibody

Characteristics: Polyclonal Antibody

Purification: Affinity purification

Immunogen: Recombinant fusion protein of human KRR1 (NP_008974.5).

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000 IF 1:50-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for KRR1

Target: KRR1 (KRR1, Small Subunit (SSU) Processome Component, Homolog (KRR1))

Alternative Name: KRR1

Background: The SSU is a large ribonucleoprotein consisting of at least 40 proteins and the U3 small nucleolar RNA. It is involved in pre-rRNA processing and ribosome assembly. The SSU is necessary for the biogenesis of the 18S rRNA. Cells that are depleted of SSU proteins will arrest in the G1 phase of the cell cycle. KRR1, also known as HRB2 (HIV-1 Rev binding protein 2) or RIP-1 (Rev interacting protein 1), is a nonribosomal component of the small subunit processome (SSU). KRR1 is 381 amino acids in length and is evolutionarily conserved among human, yeast, fly, nematode and rice. KRR1 localizes to the nucleolus and is highly expressed in dividing cells. It contains one conserved KH domain (RNA-binding motif) and is a crucial component of the SSU, required for both rRNA maturation and ribosome biogenesis.

Molecular Weight:

Observed_MW: 44 kDa

Calculated_MW: 36 kDa/43 kDa

Gene ID: 11103

UniProt: Q13601