Adenylosuccinate Lyase antibody

Catalog No. ABIN7262084

This Rabbit Polyclonal antibody specifically detects Adenylosuccinate Lyase in WB and IF. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for Adenylosuccinate Lyase antibody (ABIN7262084)

Target: Adenylosuccinate Lyase (ADSL)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Adenylosuccinate Lyase antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-Adenylosuccinate Lyase Antibody

Characteristics: Polyclonal Antibody

Purification: Affinity purification

Immunogen: Recombinant fusion protein of human ADSL (NP_000017.1).

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000 IF 1:20-1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Adenylosuccinate Lyase

Target: Adenylosuccinate Lyase (ADSL)

Alternative Name: ADSL

Background: The protein encoded by this gene belongs to the lyase 1 family. It is an essential enzyme involved in purine metabolism, and catalyzes two non-sequential reactions in the de novo purine biosynthetic pathway: the conversion of succinylaminoimidazole carboxamide ribotide (SAICAR) to aminoimidazole carboxamide ribotide (AICAR) and the conversion of adenylosuccinate (S-AMP) to adenosine monophosphate (AMP). Mutations in this gene are associated with adenylosuccinase deficiency (ADSLD), a disorder marked with psychomotor retardation, epilepsy or autistic features. Alternatively spliced transcript variants have been found for this gene.

Molecular Weight:

Observed_MW: 55 kDa

Calculated_MW: 48 kDa/54 kDa

Gene ID: 158

UniProt: P30566

Pathways: Ribonucleoside Biosynthetic Process