PYGL antibody

Catalog No. ABIN7262605

The Rabbit Polyclonal anti-PYGL antibody is suitable to detect PYGL in samples from Human, Rat and Mouse. It has been validated for IF.

Quick Overview for PYGL antibody (ABIN7262605)

Target: PYGL (phosphorylase, Glycogen, Liver (PYGL))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PYGL antibody is un-conjugated

Application: Immunofluorescence (IF)

Product Details anti-PYGL Antibody

Characteristics: Polyclonal Antibody

Purification: Affinity purification

Immunogen: Recombinant fusion protein of human PYGL (NP_002854.3).

Isotype: IgG

Application Details

Application Notes: IF 1:50-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for PYGL

Target: PYGL (phosphorylase, Glycogen, Liver (PYGL))

Alternative Name: PYGL

Background: This gene encodes a homodimeric protein that catalyses the cleavage of alpha-1,4-glucosidic bonds to release glucose-1-phosphate from liver glycogen stores. This protein switches from inactive phosphorylase B to active phosphorylase A by phosphorylation of serine residue 15. Activity of this enzyme is further regulated by multiple allosteric effectors and hormonal controls. Humans have three glycogen phosphorylase genes that encode distinct isozymes that are primarily expressed in liver, brain and muscle, respectively. The liver isozyme serves the glycemic demands of the body in general while the brain and muscle isozymes supply just those tissues. In glycogen storage disease type VI, also known as Hers disease, mutations in liver glycogen phosphorylase inhibit the conversion of glycogen to glucose and results in moderate hypoglycemia, mild ketosis, growth retardation and hepatomegaly. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene ID: 5836

UniProt: P06737

Pathways: Carbohydrate Homeostasis, Cellular Glucan Metabolic Process