PKC antibody (pSer660)

Catalog No. ABIN7265230

This Rabbit Polyclonal antibody specifically detects PKC in WB. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for PKC antibody (pSer660) (ABIN7265230)

Target: PKC (PKC pan) (Protein Kinase C (pan) (PKC pan))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PKC antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PKC Antibody

Binding Specificity: pSer660

Characteristics: Phosphorylated antibody

Purification: Affinity purification

Immunogen: A phospho specific peptide corresponding to residues surrounding Ser660 of human PKC (pan) betaII

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for PKC

Target: PKC (PKC pan) (Protein Kinase C (pan) (PKC pan))

Alternative Name: PKC

Background: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes.

Molecular Weight:

Observed_MW: 95 kDa

Calculated_MW: 59 kDa/67 kDa/74- 83 kDa

Gene ID: 5578, 5579, 5580

UniProt: P17252, P05771, Q05655, Q02156, P24723, Q04759

Pathways: Positive Regulation of Response to DNA Damage Stimulus