CD8B antibody
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- Target See all CD8B Antibodies
- CD8B (CD8b Molecule (CD8B))
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Reactivity
- Rat
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This CD8B antibody is un-conjugated
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Application
- Flow Cytometry (FACS), Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Functional Studies (Func)
- Purpose
- Anti-Rt CD8b Purified Low Endotoxin
- Specificity
- The mouse monoclonal antibody 341 (also known as 34.1) recognizes rat CD8b, the 32-34 kDa beta chain of the CD8 coreceptor (extracellular epitope), expressed on T cell subsets and some other cell types, such as macrophages.
- Purification
- Purified by protein-A affinity chromatography.
- Endotoxin Level
- Endotoxin level is less than 0.01 EU/µg of the protein, as determined by the LAL test.
- Immunogen
- CD8 positive Wistar rat splenic T cell hybridomas
- Clone
- 341
- Isotype
- IgG1 kappa
- Top Product
- Discover our top product CD8B Primary Antibody
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anti-CD8b Molecule (CD8B) antibody
CD8B Reactivity: Rat FACS, WB, IP, IHC (fro) Host: Mouse Monoclonal 341 unconjugated
anti-CD8b Molecule (CD8B) antibody (FITC)CD8B Reactivity: Rat FACS Host: Mouse Monoclonal 341 FITC
anti-CD8b Molecule (CD8B) (AA 51-150) antibodyCD8B Reactivity: Human WB, ELISA, IHC (fro), IF (cc), IF (p), ICC, IHC (p) Host: Rabbit Polyclonal unconjugated
anti-CD8b Molecule (CD8B) antibody (PE)CD8B Reactivity: Rat FACS Host: Mouse Monoclonal 341 PE
anti-CD8b Molecule (CD8B) (AA 22-170) antibodyCD8B Reactivity: Human WB, IHC, ICC Host: Rabbit Polyclonal unconjugated
anti-CD8b Molecule (CD8B) (AA 22-170) antibodyCD8B Reactivity: Human ELISA, IHC Host: Rabbit Polyclonal unconjugated
anti-CD8b Molecule (CD8B) antibody (PE)CD8B Reactivity: Mouse FACS Host: Rat Monoclonal H35-17-2 PE
anti-CD8b Molecule (CD8B) antibody (FITC)CD8B Reactivity: Chicken FACS Host: Mouse Monoclonal EP42 FITC
anti-CD8b Molecule (CD8B) (AA 1-243) antibodyCD8B Reactivity: Human WB, IP Host: Rabbit Polyclonal unconjugated
anti-CD8b Molecule (CD8B) (AA 22-170) antibodyCD8B Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
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- Application Notes
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Flow cytometry: Recommended dilution: 1-4 μg/mL.
Functional application: In vitro stimulation, in vivo depletion. - Restrictions
- For Research Use only
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- Concentration
- 1 mg/mL
- Buffer
- Phosphate buffered saline (PBS), pH 7.4
- Storage
- 4 °C
- Storage Comment
- Store at 2-8°C. Do not freeze.
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- Target
- CD8B (CD8b Molecule (CD8B))
- Alternative Name
- CD8b (CD8B Products)
- Background
- CD8b molecule,The CD8b (CD8 beta) subunit of CD8 T cell coreceptor is expressed in CD8 alpha/beta heterodimers on majority of MHC I-restricted conventional T cells and thymocytes and in CD8 alpha/alpha homodimers on subsets of memory T cells, intraepithelial lymphocytes, NK cells, macrophages, mast cells, and dendritic cells. Regulation of CD8 beta level on T cell surface seems to be an important mechanism to control their effector function. Assembly of CD8 alpha/beta but not alpha/alpha dimers is connected with formation or localization to the lipid rafts. Recruiting triggered TCR complexes to these membrane microdomains as well as affinity of TCR to MHC I is modulated by CD8, thereby affecting the functional diversity of the TCR signaling.,Ly-3, Ly-C, Lyt-3
- Gene ID
- 926
- UniProt
- P10966
- Pathways
- TCR Signaling
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