Histone H4 antibody (H4K12ac)

Catalog No. ABIN703526

There is 1 publication for this product available. The Rabbit Polyclonal anti-Histone H4 antibody is suitable to detect Histone H4 in samples from Human. It has been validated for IHC (p), IF (cc), IF (p) and IHC (fro).

Quick Overview for Histone H4 antibody (H4K12ac) (ABIN703526)

Target: Histone H4 (HISTH4)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Histone H4 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-Histone H4 Antibody

Binding Specificity: H4K12ac

Purpose: Histone H4 (Acetyl K12) Polyclonal Antibody

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Dog,Cow,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic acetylpeptide derived from human Histone H4 around acetylation site of Lys12

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-Histone H4 antibody (ABIN703526)

Yeo, Becherel, Luff, Graham, Richard, Lavin: "Senataxin controls meiotic silencing through ATR activation and chromatin remodeling." in: Cell discovery, Vol. 1, pp. 15025, (2016) (PubMed).

Target Details for Histone H4

Target: Histone H4 (HISTH4)

Alternative Name: Histone H4

Background:

Synonyms: Histone H4 Acetyl K12, Histone H4 Acetyl Lys12, Acetyl-Histone H4 Lys12, H4F2, H4FN, HIST1H4, HIST2H4, HISTH4H4, methyl histone H4, histone H4, H4_HUMAN.

Background: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails, instead, they contain a palindromic termination element. [provided by RefSeq, Jul 2008].

Gene ID: 121504