RAE1 antibody (AA 101-200) (Biotin)

Catalog No. ABIN704173

This Rabbit Polyclonal antibody specifically detects RAE1 in ELISA, IHC (p) and IHC (fro). It exhibits reactivity toward Human.

Quick Overview for RAE1 antibody (AA 101-200) (Biotin) (ABIN704173)

Target: RAE1 (RAE1 RNA Export 1 Homolog (S. Pombe) (RAE1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RAE1 antibody is conjugated to Biotin

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-RAE1 Antibody (Biotin)

Binding Specificity: AA 101-200

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human RAE1

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for RAE1

Target: RAE1 (RAE1 RNA Export 1 Homolog (S. Pombe) (RAE1))

Alternative Name: RAE1

Background:

Synonyms: RAE-1, MIG 14, MIG14, Mnrp 41, Mnrp41, mRNA associated protein mrnp 41, mRNA binding protein 41 kD, mRNA export protein, MRNP 41, MRNP41, RAE 1, RAE1 RNA export 1 S.pombe homolog, RAE1 homolog, Rae1 protein homolog, RAE1 RNA export 1 homolog, RNA export 1, RNA export 1 homolog, Homolog of yeast Rae1 mRNA associated protein of 41 kDa. RAE1L_HUMAN

Background: Mutations in Rae1 and Gle2(Saccharomyces cerevisae homolog) genes have been shown to result in accumulation of poly(A)-containing mRNA in the nucleus, suggesting that the encoded proteins are involved in RNA export. It contains four WD40 motifs, and has been shown to localize to distinct foci in the nucleoplasm, to the nuclear rim, and to meshwork-like structures throughout the cytoplasm. This gene is thought to be involved in nucleocytoplasmic transport, and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. Depletion of Rae1 from extracts or cells severely inhibits mitotic spindle assembly. Alternatively spliced transcript variants encoding the same protein have been found for this gene.

Gene ID: 8480

Pathways: SARS-CoV-2 Protein Interactome