Aquaporin 5 antibody (C-Term, Intracellular)

Catalog No. ABIN7887072

The Rabbit Polyclonal anti-Aquaporin 5 antibody (ABIN7887072) specifically detects Aquaporin 5 in WB, IHC, IF and IC. The antibody is reactive with Rat samples.

Quick Overview for Aquaporin 5 antibody (C-Term, Intracellular) (ABIN7887072)

Target: Aquaporin 5 (AQP5)

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Aquaporin 5 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunochromatography (IC)

Product Details anti-Aquaporin 5 Antibody

Binding Specificity: AA 251-265, C-Term, Intracellular

Purpose: A Rabbit Polyclonal Antibody to Aquaporin 5 Channel

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Mouse - identical, human - 10,16 amino acid residues identical

Characteristics: Anti-Aquaporin 5 Antibody (ABIN7042941, ABIN7045200 and ABIN7045201) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot, immunocytochemistry and immunohistochemistry applications. It has been designed to recognize AQP5 from mouse, rat, and human samples.

Purification: Affinity purified on immobilized antigen.

Immunogen: (C)DHREERKKTIELTAH corresponding to amino acid residues 251-265 of rat AQP5

Isotype: IgG

Application Details

Application Notes:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Comment:

Cited Application: IHC|ICC|Whole Tissue Staining

Negative Control: (ABIN7234767)

Blocking Peptide: (ABIN7234767)

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Target Details for Aquaporin 5

Target: Aquaporin 5 (AQP5)

Alternative Name: AQP5

Background:

Synonyms: AQP5

Description: The importance of the aquaporin water channels was underscored by awarding the 2003 Nobel Prize in Chemistry to Peter Agre "for the discovery of water channels". Today, eleven mammalian proteins that belong to the aquaporin family have been identified. The proteins present a conserved structure of six transmembrane domains with intracellular N- and C-termini. Aquaporin 5 (AQP5) is expressed in secretory glands, lung and eye, where it works in modulating the rate of fluid release. Since a number of pathological conditions including pulmonary edema, respiratory distress syndrome and congestive heart failure are characterized by disrupted fluid transport, it has been suggested that modulation of the expression of AQP5 could be a novel modality of treatment of the above illnesses. Indeed, several studies have shown that AQP5 expression is downregulated in animal models of acute lung infection.

Gene ID: 25241

NCBI Accession: NM_001651

UniProt: P47864