NMUR1 antibody (Extracellular, Loop 3)

Catalog No. ABIN7886649

This Rabbit Polyclonal antibody specifically detects NMUR1 in WB, FACS, IHC and LCI. It exhibits reactivity toward Rat.

Quick Overview for NMUR1 antibody (Extracellular, Loop 3) (ABIN7886649)

Target: NMUR1 (Neuromedin U Receptor 1 (NMUR1))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NMUR1 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (IHC), Live Cell Imaging (LCI)

Product Details anti-NMUR1 Antibody

Binding Specificity: AA 316-331, Extracellular, Loop 3

Purpose: A Rabbit Polyclonal antibody to NMUR1 (extracellular)

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Human - 12 out of 16 amino acid residues identical, Mouse - 10 out of 16 amino acid residues identical

Characteristics: A rabbit polyclonal antibody to NMUR1 (extracellular)

Purification: Affinity purified on immobilized antigen.

Immunogen: (C)DRLMWSMVSHWTDGLR, corresponding to amino acid residues 316 - 331 of rat NMUR1

Isotype: IgG

Application Details

Application Notes:

WB: 1:400-1:500

FC: 2.5 μg per reaction

ICC: The optimal concentration should be determined by the user

IHC: 1:300

IP: The optimal concentration should be determined by the user

Comment:

Negative Control: (ABIN7236064)

Blocking Peptide: (ABIN7236064)

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Target Details for NMUR1

Target: NMUR1 (Neuromedin U Receptor 1 (NMUR1))

Alternative Name: NMUR1

Background:

Synonyms: Neuromedin-U Receptor 1, G Protein-Coupled Receptor 66, GPR66

Description: Neuromedin U Receptor 1 (NMUR1) is one of the two receptors for the neuropeptide Neuromedin U (NMU). NMUR1 and the second receptor NMUR2 are members of the G protein coupled receptors (GPCRs) superfamily 1.NMU is a neuropeptide with potent activity on smooth muscles that is widely distributed in the gut and central nervous system. NMU interaction with one of its two receptors- NMU1R or NMU2R, mediates the stimulation of smooth muscles, increase of blood pressure, alteration of ion transport in the gut, control of local blood flow and regulation of adrenocortical function1-2.NMU1R is abundantly expressed in peripheral tissues including lung, GI tract, pancreatic islets, testis, adipose, immune tissues, and dorsal root ganglia2, and due to its diverse functions it is a very appealing drug and research candidate.

Gene ID: 65276

NCBI Accession: NM_006056

UniProt: Q9JJI5