KCNG1 antibody (Extracellular)

Catalog No. ABIN7043541

Product Details anti-KCNG1 Antibody

Target: KCNG1 (Potassium Voltage-Gated Channel, Subfamily G, Member 1 (KCNG1))

Binding Specificity: AA 325-337, Extracellular

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KCNG1 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Western Blotting (WB), Immunofluorescence (IF)

Purpose: A Rabbit Polyclonal Antibody to KCNG1 (KV6.1) Channel

Specificity: 2nd extracellular loop

Cross-Reactivity: Mouse, Rat

Predicted Reactivity: Rat - identical, human - 11,13 amino acid residues identical

Characteristics: Anti-KCNG1 (Kv6.1) (extracellular) Antibody is directed against an extracellular epitope of the mouse KV6.1 channel. Anti-KCNG1 (KV6.1) (extracellular) Antibody (ABIN7043541 and ABIN7045038) can be used in western blot and immunohistochemistry applications. It is specially suited for live cell imaging. It has been designed to recognize KV6.1 from rat, mouse and human samples.

Purification: Affinity purified on immobilized antigen.

Immunogen:

Immunogen: Synthetic peptide

Immunogen Sequence: (C)RRKPSTGNSYLDK, corresponding to amino acid residues 325-337 of mouse KV6.1

Isotype: IgG

Application Details

Application Notes:

Antigen preadsorption control: 1 μg peptide per 1 μg antibody

Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:200

Application Dilutions Western blot wb: 1:400

Comment:

Negative Control: (ABIN7236551)

Blocking Peptide: (ABIN7236551)

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW).

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Storage: 4 °C,-20 °C

Storage Comment:

Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Target Details for KCNG1

Target: KCNG1 (Potassium Voltage-Gated Channel, Subfamily G, Member 1 (KCNG1))

Alternative Name: KCNG1 (KCNG1 Products)

Background: Potassium voltage-gated channel subfamily G member 1,Voltage-gated K+ channels are transmembrane proteins consisting of four α-subunits arranged in a radially symmetric fashion around a central aqueous pore. Each α-subunit consists of six transmembrane segments (S1-S6) with cytoplasmic NH2- and COOH-termini.In mammals, a large family of genes encodes α-subunits: KV1 (homologous to Drosophila Shaker), KV2 (Shab), KV3 (Shaw), KV4 (Shal), KV5, KV6, and KV91. The sparsely populated KV channel subfamilies KV5 and KV6 each contain one member, KV5.1 and KV6.12. KV6 channels are electrically silent and no functional role has been suggested for these channels3. A recent study found that KV6.1 forms functional channels specifically with KV2.13. It was also found that KV2.1 and KV6.1 mRNAs colocalize to the piriform cortex, hippocampus, dendate gyrus and olfactory tubercle in the brain4 and to SA node, atria and ventricle in the heart5. This suggests that KV6.1 may be physiologically important in generating an increased number of KV channel phenotypes even though it does not itself form functional homomultimeric channels3.

Alternative names: KCNG1 (KV6.1), Potassium voltage-gated channel subfamily G member 1

Gene ID: 241794

NCBI Accession: NM_002237

UniProt: A2BDX4