SSTR1 antibody (Extracellular, N-Term)

Catalog No. ABIN7887136

The Rabbit Polyclonal anti-SSTR1 antibody (ABIN7887136) specifically detects SSTR1 in WB and IHC. The antibody is reactive with Rat samples.

Quick Overview for SSTR1 antibody (Extracellular, N-Term) (ABIN7887136)

Target: SSTR1 (Somatostatin Receptor 1 (SSTR1))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SSTR1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-SSTR1 Antibody

Binding Specificity: AA 26-40, Extracellular, N-Term

Purpose: A Rabbit Polyclonal Antibody to Somatostatin Receptor Type 1

Cross-Reactivity: Mouse, Rat

Predicted Reactivity: Mouse - identical, human - 13,15 amino acid residues identical

Characteristics: Anti-Somatostatin Receptor Type 1 (extracellular) Antibody (ABIN7043763 and ABIN7045262) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize SSTR1 from rat, mouse, and human samples.

Purification: Affinity purified on immobilized antigen.

Immunogen: CSRGPGSGAADGMEE, corresponding to amino acid residues 26-40 of rat SSTR1

Isotype: IgG

Application Details

Application Notes:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: 1:1000

IP: The optimal concentration should be determined by the user

Comment:

Negative Control: (ABIN7237232)

Blocking Peptide: (ABIN7237232)

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Target Details for SSTR1

Target: SSTR1 (Somatostatin Receptor 1 (SSTR1))

Alternative Name: SSTR1

Background:

Synonyms: SSTR1, SS1R, SRIF-2, SRIF2A

Description: Somatostatin is a small cyclic peptide that is widely expressed throughout the central nervous system and peripheral tissues.1 In peripheral tissues, somatostatin exerts inhibitory effects on secretion processes, whereas in the brain it acts as a neurotransmitter in both a stimulatory and inhibitory manner.1,2Somatostatin mediates its action via six high affinity G-protein coupled receptors (SSTR1, SSTR2a, SSTR2b, SSTR3, SSTR4 and SSTR5) which are encoded by five genes.1,2 Expression of the different receptors is developmentally regulated in a time and tissue-specific manner.2Somatostatin receptors have been found on a variety of neuroendocrine tumors, such as paragangliomas, carcinoids and breast tumors.3 Synthetic peptide derivatives of somatostatin have been successfully used in the treatment of neuroendocrine malignancies and in in vivo imaging of tumors that are positive to somatostatin receptors.4

Gene ID: 25033

NCBI Accession: NM_001049

UniProt: P28646