Recombinant TRKA antibody

Catalog No. ABIN7072322

Product Details anti-TRKA Antibody

Target: TRKA (NTRK1) (Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Chimeric

Conjugate: This TRKA antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Surface Plasmon Resonance (SPR), Blocking Peptide (BP)

Purpose: Anti-TrkA [MNAC13], Rabbit IgG, kappa

Specificity: This antibody binds to the extracellular domain of TrkA. It was shown not to cross react with TrkB . Moreover MNAC13 is specific to TrkA with negligible reactivity to TrkB and TrkC.

Characteristics:

Original Species of Ab: Mouse

Original Format of Ab: IgG1

Purification: Protein A affinity purified

Immunogen: Human TrkA ECD.

Clone: MNAC13

Isotype: IgG kappa

Application Details

Application Notes: This antibody binds to human TrkA, a receptor tyrosine kinase involved in the development and the maturation of the CNS and the PNS through regulation of proliferation, differentiation, and survival of the sympathetic and nervous neurons. It is a receptor for NGF and phosphorylates several downstream proteins regulating a variety of signalling cascades. This antibody neutralizes the NGF-TrkA interation.

Comment:

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Target Details for TRKA

Target: TRKA (NTRK1) (Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1))

Alternative Name: TrkA (NTRK1 Products)

Background: Tropomyosin Receptor Kinase, NTRK1, MTC, TRK, TRK1, TRKA, Trk-A, p140-TrkA, neurotrophic receptor tyrosine kinase 1, High Affinity Nerve Growth Factor Receptor, Tyrosine Kinase Receptor A

UniProt: P04629

Pathways: RTK Signaling, Neurotrophin Signaling Pathway, cAMP Metabolic Process