Recombinant FOLR2 antibody

Catalog No. ABIN7072338

The Rat Monoclonal anti-FOLR2 antibody (Clone CL10) (ABIN7072338) specifically detects FOLR2 in WB and IHC. The antibody is reactive with Mouse samples.

Quick Overview for Recombinant FOLR2 antibody (ABIN7072338)

Target: FOLR2 (Folate Receptor 2 (Fetal) (FOLR2))

Antibody Type: Recombinant Antibody

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This FOLR2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: CL10

Product Details anti-FOLR2 Antibody

Purpose: Anti-Folate receptor beta [CL10], Rat IgG2a, kappa

Characteristics:

Original Species of Ab: Rat

Original Format of Ab: IgG2a

Purification: Protein A affinity purified

Immunogen: FRbeta -transfected RBL2H3 cells.

Isotype: IgG2a kappa

Application Details

Application Notes: The antibody binds specifically to FRβ, a member of the folate receptor family. The receptor binds with high affinity to folic acid and folic acid derivatives, and transports 5-methyltetrahydrofolate into the cell. The receptor is expressed on the surface of tumour associated macrophages (TAMs) that promote growth and metastasis of tumours such as gliomas and colon, breast and lung carcinomas. Research has shown FRβ is only expressed on activated macrophages, and thereby a monoclonal antibody that targets the receptor can be useful in the diagnosis of the cancer. Furthermore, the antibody may be conjugated with a toxin, delivering the drug only to TAMs and not to healthy macrophages.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Target Details for FOLR2

Target: FOLR2 (Folate Receptor 2 (Fetal) (FOLR2))

Alternative Name: Folate receptor beta

Background: FRβ, Folate receptor 2, Folate-binding protein 2.

UniProt: Q05685

Pathways: Dicarboxylic Acid Transport