Recombinant CCR4 (Mogamulizumab Biosimilar) antibody
Quick Overview for Recombinant CCR4 (Mogamulizumab Biosimilar) antibody (ABIN7072382)
Target
Antibody Type
Reactivity
Host
Clonality
Conjugate
Application
Clone
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Purpose
- Anti-CCR4 [KW-0761 (Mogamulizumab)], Rabbit IgG, kappa
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Specificity
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This antibody is specific for human CCR4, a chemokine receptor that is preferentially expressed by Th2 and regulatory T (Treg) cells. CCR4 is also detected on basophils, platelets, monocytes and brain microvascular and coronary artery endothelial cells.
Application Notes original Clone: The clinically used format of this antibody (which underwent additional de-fucosylation to increase antibody-dependent cellular cytotoxicity (ADCC)), has significant clinical activity in heavily pretreated patients with mycosis fungoides and Sézary syndrome, and is associated with an overall response rate of 36.8 % and a median duration of response of 10.4 months (Duvic et al, 2014). It was shown to CCR4-expressing cells by antibody-dependent, cell-mediated cytotoxicity (ADCC). Therapeutically, this results in a dual mechanism of action, in addition to directly targeting malignant T cells over-expressing CCR4, this antibody also depletes T reg cells, an important therapeutic target in human cancers. This antibody is well-tolerated, and administration does not appear to trigger clinically significant autoimmune complications in phase 1/2 trials (Duvic et al, 2014). This antibody has been approved in Japan for the treatment of relapsed or refractory adult T-cell leukemia/lymphoma, and is in clinical trials for solid cancers. For the avoidance of doubt - the material produced by Absolute Antibody has not been de-fucosylated.
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Characteristics
- This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.
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Purification
- Protein A affinity purified
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Immunogen
- This antibody was prepared by humanization of a mouse anti-CCR4 mAb.
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Isotype
- IgG, kappa
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anti-CCR4 (Mogamulizumab Biosimilar) antibody
Research Grade Reactivity: Human FACS Host: Humanized Monoclonal unconjugated
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Comment
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OriginalSpeciesName: Human
OriginalFormat: IgG1
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Restrictions
- For Research Use only
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Concentration
- 1 mg/mL
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Buffer
- PBS with 0.02 % Proclin 300.
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Preservative
- ProClin
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Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Storage
- 4 °C,-20 °C
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Storage Comment
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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- CCR4 (Mogamulizumab Biosimilar)
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Target Type
- Biosimilar
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Background
- CD194, CKR-4, CCR-4, CCR4, K5-5
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UniProt
- P51679
Target
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