Recombinant MME antibody

Catalog No. ABIN7072450

This Mouse Monoclonal antibody specifically detects MME in WB, IP and IF. It exhibits reactivity toward Human.

Quick Overview for Recombinant MME antibody (ABIN7072450)

Target: MME (Membrane Metallo-Endopeptidase (MME))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MME antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF)

Clone: NL-1

Product Details anti-MME Antibody

Purpose: Anti-CD10 [NL-1], Mouse IgG2a, kappa

Specificity: This antibody reacts with human CD10. CD10 is a widely-expressed cell-surface metalloprotease, responsible for the cleavage of multiple peptide hormones at target tissues. CD10 is also a common marker for acute lymphocytic leukaemia.

Characteristics:

Original Species of Ab: Mouse

Original Format of Ab: IgG2a

Purification: Protein A affinity purified

Immunogen: BALB/c mice were immunised with acute lymphocytic leukaemia cells from a human leukaemia patient. Splenocytes were obtained from immunised mice and fused with MOPC-21 NS/1 myeloma cells to generate a hybridoma.

Isotype: IgG2a kappa

Application Details

Application Notes: NL-1 was shown to react with several leukaemic cell lines using immune adherence assays (Ueda et al, 1982). These authors also confirmed that NL-1 is specific for CD10 using IP.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Target Details for MME

Target: MME (Membrane Metallo-Endopeptidase (MME))

Alternative Name: CD10

Target Type: Chemical

Background: Neprilysin, Cluster of Differentiation 10, Membrane metallo-endopeptidase, MME, Neutral endopeptidase 24.11, Neutral endopeptidase, NEP, Common acute lymphocytic leukaemia antigen, CALLA, Skin fibroblast elastase, SFE, CMT2T, SCA43, Atriopeptidase, Enkephalinase

UniProt: P08473

Pathways: RTK Signaling, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Smooth Muscle Cell Migration