Recombinant Transferrin Receptor antibody

Catalog No. ABIN7072542

This anti-Transferrin Receptor antibody is a Rabbit Chimeric antibody detecting Transferrin Receptor in FACS and Dep. Suitable for Mouse.

Quick Overview for Recombinant Transferrin Receptor antibody (ABIN7072542)

Target: Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))

Antibody Type: Recombinant Antibody

Reactivity: Mouse

Host: Rabbit

Clonality: Chimeric

Conjugate: This Transferrin Receptor antibody is un-conjugated

Application: Flow Cytometry (FACS), Depletion (Dep)

Clone: R17 217-1-3

Product Details anti-Transferrin Receptor Antibody

Purpose: Anti-Transferrin receptor [R17 217.1.3], Rabbit IgG, kappa

Specificity: The transferrin receptor is necessary for cellular iron uptake by the process of receptor-mediated endocytosis. Mice that are deficient in this receptor show impaired erythroid development and abnormal iron homeostasis.

Characteristics:

Original Species of Ab: Rat

Original Format of Ab: IgG2a

Purification: Protein A affinity purified

Immunogen: The antibody was obtained from a fusion of the murine myeloma S 194/5.XXO.BU. 1 with spleen cells from a BDIX rat immunized with the Friend erythroleukemia 745.6.

Isotype: IgG kappa

Application Details

Application Notes: R17 217.1.3 was used in conjunction with flow cytometry to identify murine hematopoietic progenitor cells expressing the transferrin receptor (Lesley et al, 1984). Injection of mice with R17 217.1.3 results in CD71+ erythroid splenocyte cell depletion (Torow et al, 2015).

Comment:

This chimeric rabbit antibody was made using the variable domain sequences of the original Rat IgG2a format, for improved compatibility with existing reagents, assays and techniques.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Target Details for Transferrin Receptor

Target: Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))

Alternative Name: Transferrin receptor

Background: CD71, Transferrin receptor protein 1, TR, , TfR1, Trfr

Pathways: Transition Metal Ion Homeostasis